IASST researchers explore the use of neurotrophin peptidomimetic drugs to treat neurodegenerative disorders

A team of researchers at the Indian Association for the Cultivation of Science (IASST) is conducting extensive studies to explore a treatment option for neurodegenerative disorders (NDs).

These disorders have posed a major health challenge globally and various studies have been conducted for a treatment course. 

The researchers are exploring the option of using peptidomimetics, synthetic compounds designed to mimic neurotrophins, as a potential solution to the limitations caused by neurodegenerative diseases. 

Neutrophils play a critical role in the survival and functioning of the nerve cells, also known as the neurons, in the nervous system. 

Peptidomimetic drugs are synthetic molecules that mimic the structure of natural proteins. Now, neurotrophin peptidomimetics are developed to target specific biological functions and can be valuable tools in drug discovery, especially when natural peptides have limitations like poor oral bioavailability or susceptibility to degradation, according to the Ministry of Science and Technology. 

Advantages of peptidomimetics:

Their improved stability and bioavailability compared to the endogenous neutrophins is one of the major advantages of peptidomimetics. This would mean that they can be delivered more effectively to the brain and maintain their therapeutic activity for a longer duration. 

Additionally, to reduce the risk of side effects, they can be designed to be specific to their target receptors. 

The research is led by Prof. Ashis K. Mukherjee and it is published in the Journal Drug Discovery Today. As per the official press release, the study has highlighted the potential of peptidomimetics to treat NDs. The study does not just restrict to the treatment of NDs but has also explored the possibility of repurposing the existing drugs as a treatment option for other diseases like cancer. 

IASST is an autonomous institute of the Department of Science and Technology (DST).

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